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Aniston then appeared in two more failed television comedy series, The Edge and Muddling Through.
Depressed over her four unsuccessful television shows, Aniston approached Warren Littlefield at a Los Angeles gas station asking for reassurance about her career.
In 2001, Aniston was in Melissa Etheridge's music video for "I Want To Be In Love".
Since 2007, Aniston has worked in a publicity campaign for the drink Smart Water; on March 7, 2011, she released a You Tube video, titled "Jennifer Aniston Goes Viral", for Smart Water, which tripled online interest in the product within 24 hours of its release.
Aniston has played the female protagonist in a number of comedies and romantic comedies.
In 2008, she co-founded the production company Echo Films.
In 2012, Aniston received a star on the Hollywood Walk of Fame.
Her box office hits include Bruce Almighty (2003), The Break-Up (2006), Marley & Me (2008), Just Go with It (2011), Horrible Bosses (2011), and We're the Millers (2013), each of which have grossed over Her most critically acclaimed roles included the role of Olivia in Friends with Money (2006), The Good Girl (2002), for which she was nominated for an Independent Spirit Award for Best Female Lead, and the drama Cake (2014), for which she received nominations for the Golden Globe Award and the Screen Actors Guild Award for Best Actress.
Her other films include Along Came Polly (2004) and He's Just Not That Into You (2009).